COMPARISON OF SODIUM LAURYL SULPHATE, SODIUM BENZOATE, POLYAETHYLENE GLYCOLUM 6000 AS LUBRICANT ON DISSOLVING TIME OF EXTRACT CIPLUKAN (Physalis angulata L.) EFFERVESCENT TABLET
Ciplukan is a plant that widely used as a traditional medicine e.g : anti-inflammatory, bronchitis, ulcers, cancer, tumors, leukemia and diabetes mellitus due to chemical compounds like saponin , terpenoids, and alkaloids. This research was conducted by making extract ciplukan effervescent tablet using sodium lauryl sulfat, PEG 6000 and sodium benzoate as lubricant. This tablet was made in 3 formula i.e 2% of sodium lauryl sulfat (F1), 3% of PEG 6000 (F2) and 4% of sodium benzoate. The tablet was evaluated for weight uniformity, size uniformity, hardness, friability, dissolve time, and pH’s test. The result shows that the comparison of lubricant can give different in dissolving time. Formula II shows the dissolving time quicker than formula I and formula III. By one way ANOVA analyses with 95% of significance level , among all combinations showed a significant differences.
