Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion
http://repository.uhamka.ac.id/638/
Aim: This study aimed to compare the diffusion rate of ketoconazole in microemulsion containing carbopol 934 or carbopol 941 as a thickener.
Methods: Ketoconazole microemulsion was made into 7 formulas with various concentrations in each type of thickener, i.e 0.1%, 0.2%, 0.3%, and one formula without thickener. Each formula were evaluated includes organoleptic, pH measurement, viscosity, particle size, potential zeta, surface tension measurement, and diffusion test.
Results: The physical properties of ketoconazole microemulsion showed liquid to gel form, yellow in color, specific odor, pH was in the range of 7.00-7.65, viscosity ranged from 2196-26037 cps, particle size was 13.6-42.2nm, zeta potential was -9.12–18.44 mV, and surface tension 30.7-64 dyne / cm. The diffusion kinetics obtained followed by the higuchi equation for the use of the two thickener, while the ketoconazole microemulsion without thickener (F1) followed the Korsmeyer-peppas equation with a diffusion rate of 9.444 %/minute. The diffusion rate of ketoconazole microemulsion with carbopol 934 (F2, F3, F4) were 4.354, 4.638, and 4.847 %/minute, respectively. Meanwhile, the diffusion rate using carbopol 941 (F5, F6, F7) were 4.695, 4.742, 4.751 %/minute, respectively.
Conclusion: It can be concluded that the diffusion rate (sig Ë‚ 0,05,) of ketoconazole in microemulsion containing carbopol 941 was faster than diffusion rate of microemulsion containing carbopol 934 at the same concentration in the microemulsion system.
